Japanese scientists begin trials for revolutionary tooth regrowth drug
Japanese scientists have announced the start of clinical trials on a drug that causes teeth to regrow. It could revolutionize medicine if it proves to be as effective in humans as it is in animals. Scientists have revealed when they plan to release the drug to the market.
31 May 2024 15:49
Scientists from Kitano Hospital in Osaka have researched the regrowth of lost permanent teeth for many years. In previous experiments on animals, the new drug caused the growth of "third-generation" teeth after milk teeth and permanent teeth in adult specimens.
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In May, a team of scientists announced that clinical trials on humans of the world's first "tooth regrowth drug" will begin in September 2024. To confirm its effectiveness, the drug will be intravenously administered to healthy individuals at the University Hospital in Kyoto.
The clinical trial will involve 30 men aged 30 to 64. Participants must lack at least one back tooth. After confirming the drug's safety, it will be administered to patients with a congenital lack of a full set of teeth to confirm its effectiveness. It is believed that congenital tooth loss affects about 1% of the population.
The tooth regrowth drug deactivates a protein called USAG-1, which inhibits tooth growth. The research team believes that in the future, it may be possible to grow teeth not only in people with congenital defects but also in those who have lost teeth due to decay or injuries. No severe side effects have been observed in animal studies conducted so far.
A "tooth regrowth drug" in six years?
Lead researcher Katsu Takahashi, head of the Department of Dentistry and Oral Surgery at Kitano Hospital, said during a press conference: "We want to do something to help those who suffer from tooth loss or lack. Although there has not been a method to provide a permanent cure so far, we believe that the demand for tooth growth is high."
Prof. Takahashi added: "The idea of growing new teeth is every dentist's dream. I have been working on this since I was a student. I was convinced that I would be able to achieve it." Scientists hope to start selling the drug in 2030.
